Applications
Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-AKE) is widely used in cosmetic and skincare formulations for premium product development.
Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-AKE) — Cosmetic Peptide Raw Material
High-purity peptide API for cosmetic formulations and skincare research
Product Overview
Dipeptide Diaminobutyroyl Benzylamide Diacetate (INCI: Dipeptide Diaminobutyroyl Benzylamide Diacetate), commercially known as Syn-AKE, Snake Venom-like Peptide, or Snake Tripeptide, CAS 823202-99-9, sequence: β-Ala-Pro-Dab-NH-Bzl · 2AcOH. CosIng listed.
Mimics the mechanism of snake venom (Waglerin-1 from Temple Viper), blocking neuromuscular transmission and relaxing facial muscles for rapid softening of expression lines. Similar mechanism to Acetyl Hexapeptide-8 but with stronger and faster-acting results. Gentle and safe, non-toxic and non-irritating.
Typical applications: Anti-wrinkle serums, eye creams, masks, emergency anti-wrinkle products. Recommended concentration: 0.005% – 0.05%.
A popular ingredient for high-end anti-aging products, the "snake venom" concept offers strong marketing appeal and high customer acceptance.
Product Identification and Specifications
| Product Name | Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-AKE) |
| CAS Number | 823202-99-9 |
| Synonyms | Dipeptide Diaminobutyroyl Benzylamide Diacetate, Syn-AKE, INCI: Dipeptide Diaminobutyroyl Benzylamide Diacetate |
| Molecular Formula | Contact for details |
| Molecular Weight | Contact for details |
| Sequence | Contact for details |
| Sequence Length | Contact for details |
| Key Modification | N/A |
| Solubility | Soluble in water and aqueous buffers |
| Pharmacological Class | Cosmetic peptide active ingredient |
| Indications | Anti-aging skincare, Wrinkle reduction, Skin firming |
| Appearance | White to off-white powder |
| Purity | ≥99% |
| Grade | Cosmetic Grade / RUO |
Mechanism of Action
Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-AKE) is a synthetic tripeptide inspired by Waglerin-1, a peptide found in the venom of the Temple Viper (Tropidolaemus wagleri). The peptide acts as a reversible antagonist of the postsynaptic nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction. By binding to the ε-subunit of the nAChR, Syn-AKE prevents acetylcholine from activating the receptor, thereby inhibiting muscle contraction without paralyzing the muscle. This produces a rapid and visible relaxation of facial expression muscles, leading to smoother skin and reduced wrinkle depth. Unlike botulinum toxin, the effect is reversible and does not require injection, making it safe for topical cosmetic use.
Key Features and Benefits
| Feature | Description | Benefit | |
|---|---|---|---|
| ≥99% Purity Verified | ≥99% purity confirmed by HPLC and LC-MS with full batch COA | Ensures consistent efficacy and safety in cosmetic formulations | |
| Complete QC Documentation | Full Certificate of Analysis with 12+ test parameters per batch | Supports regulatory compliance and quality assurance programs | |
| EU REACH / FDA Compliant | Manufacturing documentation supports global cosmetic regulations | Enables rapid market entry in North America, Europe, and Asia | |
| Multiple Dosage Forms | Available as raw powder and lyophilized powder | Flexibility for different formulation requirements and stability needs | |
| Scalable Production | Production capacity from gram to multi-kilogram batches | Supports projects from R&D phase through commercial launch | |
| 3-5 Day Lead Time | In-stock items ship within 3-5 business days globally | Minimizes inventory costs and accelerates product development timelines |
Applications and Formulations
Quality Standards and COA Specifications
| Test Item | Specification | Method |
|---|---|---|
| Appearance | White to off-white powder | Visual Inspection |
| Peptide Purity (HPLC) | ≥99.0% | RP-HPLC |
| Identity (MS) | Molecular weight matches theoretical | LC-MS/ESI-MS |
| Single Impurity | ≤0.5% | RP-HPLC |
| Total Impurities | ≤1.0% | RP-HPLC |
| Water Content | ≤5.0% | Karl Fischer |
| Acetate Content | Report | HPLC |
| pH (1% solution) | 3.0 - 6.0 | pH Meter |
| Microbial Limits | TAMC ≤100 CFU/g; TYMC ≤50 CFU/g | USP <61> |
| Endotoxin | <10 EU/g | LAL Test |
Full batch-specific COA provided with each shipment. Contact us for historical COA requests.
Packaging and Storage
Packaging Details
Storage and Handling
Regulatory Documentation Support
Certificate of Analysis (COA)
Full batch-specific COA with HPLC, MS, and microbial test results provided with every shipment
Material Safety Data Sheet (MSDS)
Comprehensive safety documentation for handling, storage, and transport
EU REACH Compliance
Registration, Evaluation, Authorization and Restriction of Chemicals documentation available
FDA Facility Registration
Manufacturing facility registered with US FDA for cosmetic ingredient production
ISO 9001 Quality Management
Quality management system certified to ISO 9001:2015 standards
Stability Data
Real-time and accelerated stability data available upon request
Global Export Capabilities
| Region | Capabilities | Documentation |
|---|---|---|
North America (USA, Canada) | Direct shipment with customs documentation; FDA-compliant COA provided | FDA-compliant COA, commercial invoice, packing list, MSDS |
Europe (EU, UK, Switzerland) | REACH-compliant documentation; CE-marked packaging available | REACH compliance statement, EDQM documentation, COA |
Asia-Pacific (Japan, Korea, Australia) | Regional logistics coordination; local language support | NMPA/PMDA-compliant packages, translated COA available |
Latin America (Brazil, Mexico) | MOH registration support; Spanish/Portuguese documentation | Spanish/Portuguese COA translations, MOH registration support |
Middle East (UAE, Saudi Arabia) | GCC registration support; halal certification available | SFDA-compliant documentation, halal certificate |
One-Stop Supply Chain Services
| Service | Description | Value |
|---|---|---|
| API Sourcing | Direct access to audited GMP manufacturing facilities with validated peptide synthesis capabilities | Ensures consistent quality and full traceability from synthesis to delivery |
| Quality Assurance | Independent batch release testing with full analytical documentation and certificate of analysis | Reduces quality risk and accelerates regulatory approval timelines |
| Technical Consultation | Dedicated account manager and technical team for formulation development and stability studies | Expert guidance throughout product development and commercialization |
| Regulatory Support | Complete CMC documentation, stability data, and regulatory filing assistance | Accelerates product registration in target global markets |
| Logistics Management | End-to-end cold chain logistics with temperature monitoring and customs brokerage | Ensures product integrity and on-time delivery worldwide |
Frequently Asked Questions
Looking for a Complete Peptide Production Solution?
Beyond raw peptide supply, Zhaoke Biotech offers end-to-end production solutions — from custom synthesis and process development to scale-up manufacturing, QC testing, and regulatory documentation. Partner with us for a seamless peptide supply chain experience.
Ready to Source High-Purity Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-AKE)?
Get a free, no-obligation quotation within 24 hours. Our technical team is standing by to assist with your formulation needs, regulatory questions, and custom requirements.