Applications
Acetyl Tetrapeptide-5 (Eyeseryl) is widely used in cosmetic and skincare formulations for premium product development.
Acetyl Tetrapeptide-5 (Eyeseryl) — Cosmetic Peptide Raw Material
High-purity peptide API for cosmetic formulations and skincare research
Product Overview
Acetyl Tetrapeptide-5 (INCI: Acetyl Tetrapeptide-5), commercially known as Eyeseryl or Eye Silk Peptide, CAS 820959-17-9, sequence: Ac-Gly-Gln-Pro-Arg-OH. CosIng listed.
Inhibits angiotensin-converting enzyme (ACE), improving microcirculation around the eyes and reducing eye bags and periorbital edema. Reduces advanced glycation end-products (AGEs), improving dark circles. Enhances periorbital skin elasticity and reduces fine lines.
Typical applications: Eye creams, eye serums, eye masks. Recommended concentration: 0.005% – 0.1%.
The go-to peptide for eye care and a standard ingredient in eye cream formulations, with stable demand in this specialized segment.
Product Identification and Specifications
| Product Name | Acetyl Tetrapeptide-5 (Eyeseryl) |
| CAS Number | 820959-17-9 |
| Synonyms | Acetyl Tetrapeptide-5, Eyeseryl, INCI: Acetyl Tetrapeptide-5 |
| Molecular Formula | C20H28N8O7 |
| Molecular Weight | 492.48 g/mol |
| Sequence | Ac-β-Ala-His-Ser-His |
| Sequence Length | 4 amino acids |
| Key Modification | N-terminal acetylation; β-alanine at position 1 |
| Solubility | Soluble in water and aqueous buffers |
| Pharmacological Class | Cosmetic peptide active ingredient |
| Indications | Dark circle reduction, Eye bag treatment, Crow's feet reduction |
| Appearance | White to off-white powder |
| Purity | ≥99% |
| Grade | Cosmetic Grade / RUO |
Mechanism of Action
Acetyl Tetrapeptide-5 (Eyeseryl) is a tetrapeptide specifically engineered for eye contour care. Its primary mechanism involves the inhibition of angiotensin-converting enzyme (ACE), which plays a key role in vascular permeability and fluid retention. By reducing ACE activity, the peptide improves microcirculation and lymphatic drainage around the eyes, significantly reducing puffiness and under-eye bags. Additionally, Acetyl Tetrapeptide-5 combats glycation — a process where sugar molecules bind to proteins like collagen, forming advanced glycation end-products (AGEs) that contribute to dark circles and skin aging. The peptide also enhances skin elasticity by stimulating collagen synthesis and inhibiting matrix metalloproteinases (MMPs) that degrade the extracellular matrix.
Key Features and Benefits
| Feature | Description | Benefit | |
|---|---|---|---|
| ≥99% Purity Verified | ≥99% purity confirmed by HPLC and LC-MS with full batch COA | Ensures consistent efficacy and safety in cosmetic formulations | |
| Complete QC Documentation | Full Certificate of Analysis with 12+ test parameters per batch | Supports regulatory compliance and quality assurance programs | |
| EU REACH / FDA Compliant | Manufacturing documentation supports global cosmetic regulations | Enables rapid market entry in North America, Europe, and Asia | |
| Multiple Dosage Forms | Available as raw powder and lyophilized powder | Flexibility for different formulation requirements and stability needs | |
| Scalable Production | Production capacity from gram to multi-kilogram batches | Supports projects from R&D phase through commercial launch | |
| 3-5 Day Lead Time | In-stock items ship within 3-5 business days globally | Minimizes inventory costs and accelerates product development timelines |
Applications and Formulations
Quality Standards and COA Specifications
| Test Item | Specification | Method |
|---|---|---|
| Appearance | White to off-white powder | Visual Inspection |
| Identity (HPLC) | Retention time matches reference standard (tR: 5.0-7.0 min) | RP-HPLC (C18, 220 nm) |
| Identity (MS) | [M+H]+ = 493.2 ± 0.5 Da | MALDI-TOF / ESI-MS |
| Peptide Purity (HPLC) | ≥98.0% (area percent) | RP-HPLC (C18, 220 nm) |
| Single Impurity | ≤0.5% | RP-HPLC |
| Total Impurities | ≤2.0% | RP-HPLC |
| Water Content | ≤8.0% | Karl Fischer |
| Acetate Content | ≤15.0% | Ion Chromatography |
| pH (1% aqueous solution) | 5.0 - 7.5 | pH Meter |
| Heavy Metals (Pb) | ≤10 ppm | ICP-MS |
| Microbial Limits | TAMC ≤100 CFU/g; TYMC ≤50 CFU/g | USP <61> |
| Endotoxin | <10 EU/g | LAL Test (USP <85>) |
| Residual Solvents | Compliant with ICH Q3C | GC-HS |
Full batch-specific COA provided with each shipment. Contact us for historical COA requests.
Packaging and Storage
Packaging Details
Storage and Handling
Regulatory Documentation Support
Certificate of Analysis (COA)
Full batch-specific COA with HPLC, MS, and microbial test results provided with every shipment
Material Safety Data Sheet (MSDS)
Comprehensive safety documentation for handling, storage, and transport
EU REACH Compliance
Registration, Evaluation, Authorization and Restriction of Chemicals documentation available
FDA Facility Registration
Manufacturing facility registered with US FDA for cosmetic ingredient production
ISO 9001 Quality Management
Quality management system certified to ISO 9001:2015 standards
Stability Data
Real-time and accelerated stability data available upon request
Global Export Capabilities
| Region | Capabilities | Documentation |
|---|---|---|
North America (USA, Canada) | Direct shipment with customs documentation; FDA-compliant COA provided | FDA-compliant COA, commercial invoice, packing list, MSDS |
Europe (EU, UK, Switzerland) | REACH-compliant documentation; CE-marked packaging available | REACH compliance statement, EDQM documentation, COA |
Asia-Pacific (Japan, Korea, Australia) | Regional logistics coordination; local language support | NMPA/PMDA-compliant packages, translated COA available |
Latin America (Brazil, Mexico) | MOH registration support; Spanish/Portuguese documentation | Spanish/Portuguese COA translations, MOH registration support |
Middle East (UAE, Saudi Arabia) | GCC registration support; halal certification available | SFDA-compliant documentation, halal certificate |
One-Stop Supply Chain Services
| Service | Description | Value |
|---|---|---|
| API Sourcing | Direct access to audited GMP manufacturing facilities with validated peptide synthesis capabilities | Ensures consistent quality and full traceability from synthesis to delivery |
| Quality Assurance | Independent batch release testing with full analytical documentation and certificate of analysis | Reduces quality risk and accelerates regulatory approval timelines |
| Technical Consultation | Dedicated account manager and technical team for formulation development and stability studies | Expert guidance throughout product development and commercialization |
| Regulatory Support | Complete CMC documentation, stability data, and regulatory filing assistance | Accelerates product registration in target global markets |
| Logistics Management | End-to-end cold chain logistics with temperature monitoring and customs brokerage | Ensures product integrity and on-time delivery worldwide |
Frequently Asked Questions
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