Applications
SNAP-8 (Acetyl Octapeptide-3) is widely used in cosmetic and skincare formulations for premium product development.
SNAP-8 (Acetyl Octapeptide-3) — Cosmetic Peptide Raw Material
High-purity peptide API for cosmetic formulations and skincare research
Product Overview
Acetyl Octapeptide-3 (INCI: Acetyl Octapeptide-3), commercially known as SNAP-8 or Octapeptide, CAS 868844-74-0, sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂. CosIng listed.
An upgraded version of Acetyl Hexapeptide-8 with a longer peptide chain for stronger anti-wrinkle efficacy. Inhibits SNARE complex formation, reducing neurotransmitter release and relaxing facial muscles. Deeply softens expression lines, particularly effective for deep wrinkles.
Typical applications: High-performance anti-wrinkle serums, creams, eye creams. Recommended concentration: 0.005% – 0.05%.
An advanced choice for premium anti-aging products, offering stronger results than Hexapeptide-8, positioned for mid-to-high-end product lines.
Product Identification and Specifications
| Product Name | SNAP-8 (Acetyl Octapeptide-3) |
| CAS Number | 868844-74-0 |
| Synonyms | SNAP-8, Acetyl Octapeptide-3, Acetyl Glutamyl Heptapeptide-3, INCI: Acetyl Octapeptide-3 |
| Molecular Formula | Contact for details |
| Molecular Weight | Contact for details |
| Sequence | Contact for details |
| Sequence Length | Contact for details |
| Key Modification | N/A |
| Solubility | Soluble in water and aqueous buffers |
| Pharmacological Class | Cosmetic peptide active ingredient |
| Indications | Anti-aging skincare, Wrinkle reduction, Skin firming |
| Appearance | White to off-white powder |
| Purity | ≥99% |
| Grade | Cosmetic Grade / RUO |
Mechanism of Action
Acetyl Octapeptide-3 (SNAP-8) is an extended-chain analog of Acetyl Hexapeptide-8, featuring an 8-amino-acid sequence (Ac-EEMQRRAD-NH₂) compared to Argireline's 6-amino-acid structure. The additional amino acids (Ala-Asp) enhance the peptide's binding affinity to the SNARE complex proteins, particularly SNAP-25 and syntaxin. By competitively inhibiting SNARE complex assembly, SNAP-8 more effectively blocks vesicle fusion and acetylcholine release at the neuromuscular junction, resulting in stronger muscle relaxation and more pronounced wrinkle reduction. The extended peptide chain also provides greater stability against proteolytic degradation, ensuring longer-lasting activity in cosmetic formulations. Clinical studies demonstrate that SNAP-8 reduces wrinkle depth by up to 35% at 10% concentration, outperforming Acetyl Hexapeptide-8 in head-to-head comparisons.
Key Features and Benefits
| Feature | Description | Benefit | |
|---|---|---|---|
| ≥99% Purity Verified | ≥99% purity confirmed by HPLC and LC-MS with full batch COA | Ensures consistent efficacy and safety in cosmetic formulations | |
| Complete QC Documentation | Full Certificate of Analysis with 12+ test parameters per batch | Supports regulatory compliance and quality assurance programs | |
| EU REACH / FDA Compliant | Manufacturing documentation supports global cosmetic regulations | Enables rapid market entry in North America, Europe, and Asia | |
| Multiple Dosage Forms | Available as raw powder and lyophilized powder | Flexibility for different formulation requirements and stability needs | |
| Scalable Production | Production capacity from gram to multi-kilogram batches | Supports projects from R&D phase through commercial launch | |
| 3-5 Day Lead Time | In-stock items ship within 3-5 business days globally | Minimizes inventory costs and accelerates product development timelines |
Applications and Formulations
Quality Standards and COA Specifications
| Test Item | Specification | Method |
|---|---|---|
| Appearance | White to off-white powder | Visual Inspection |
| Peptide Purity (HPLC) | ≥99.0% | RP-HPLC |
| Identity (MS) | Molecular weight matches theoretical | LC-MS/ESI-MS |
| Single Impurity | ≤0.5% | RP-HPLC |
| Total Impurities | ≤1.0% | RP-HPLC |
| Water Content | ≤5.0% | Karl Fischer |
| Acetate Content | Report | HPLC |
| pH (1% solution) | 3.0 - 6.0 | pH Meter |
| Microbial Limits | TAMC ≤100 CFU/g; TYMC ≤50 CFU/g | USP <61> |
| Endotoxin | <10 EU/g | LAL Test |
Full batch-specific COA provided with each shipment. Contact us for historical COA requests.
Packaging and Storage
Packaging Details
Storage and Handling
Regulatory Documentation Support
Certificate of Analysis (COA)
Full batch-specific COA with HPLC, MS, and microbial test results provided with every shipment
Material Safety Data Sheet (MSDS)
Comprehensive safety documentation for handling, storage, and transport
EU REACH Compliance
Registration, Evaluation, Authorization and Restriction of Chemicals documentation available
FDA Facility Registration
Manufacturing facility registered with US FDA for cosmetic ingredient production
ISO 9001 Quality Management
Quality management system certified to ISO 9001:2015 standards
Stability Data
Real-time and accelerated stability data available upon request
Global Export Capabilities
| Region | Capabilities | Documentation |
|---|---|---|
North America (USA, Canada) | Direct shipment with customs documentation; FDA-compliant COA provided | FDA-compliant COA, commercial invoice, packing list, MSDS |
Europe (EU, UK, Switzerland) | REACH-compliant documentation; CE-marked packaging available | REACH compliance statement, EDQM documentation, COA |
Asia-Pacific (Japan, Korea, Australia) | Regional logistics coordination; local language support | NMPA/PMDA-compliant packages, translated COA available |
Latin America (Brazil, Mexico) | MOH registration support; Spanish/Portuguese documentation | Spanish/Portuguese COA translations, MOH registration support |
Middle East (UAE, Saudi Arabia) | GCC registration support; halal certification available | SFDA-compliant documentation, halal certificate |
One-Stop Supply Chain Services
| Service | Description | Value |
|---|---|---|
| API Sourcing | Direct access to audited GMP manufacturing facilities with validated peptide synthesis capabilities | Ensures consistent quality and full traceability from synthesis to delivery |
| Quality Assurance | Independent batch release testing with full analytical documentation and certificate of analysis | Reduces quality risk and accelerates regulatory approval timelines |
| Technical Consultation | Dedicated account manager and technical team for formulation development and stability studies | Expert guidance throughout product development and commercialization |
| Regulatory Support | Complete CMC documentation, stability data, and regulatory filing assistance | Accelerates product registration in target global markets |
| Logistics Management | End-to-end cold chain logistics with temperature monitoring and customs brokerage | Ensures product integrity and on-time delivery worldwide |
Frequently Asked Questions
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