Applications
Oligopeptide-1 (EGF-like Peptide) is widely used in cosmetic and skincare formulations for premium product development.
Oligopeptide-1 (EGF-like Peptide) — Cosmetic Peptide Raw Material
High-purity peptide API for skin repair and barrier recovery formulations
Product Overview
Oligopeptide-1 (INCI: Oligopeptide-1), commercially known as EGF-like Peptide or Epidermal Repair Peptide, CAS 126439-82-5. A 13-amino-acid polypeptide that mimics EGF (Epidermal Growth Factor). CosIng listed.
Mimics EGF action, promoting epidermal cell proliferation and differentiation. Accelerates skin barrier repair and wound healing. Improves skin elasticity and reduces fine lines. Soothes redness and improves sensitive skin.
Typical applications: Repair serums, post-aesthetic recovery products, sensitive skin care, lyophilized powder. Recommended concentration: 0.0001% – 0.01%.
The representative peptide for skin repair, popular for post-aesthetic recovery and sensitive skin care. A core ingredient in lyophilized powder products.
Product Identification and Specifications
| Product Name | Oligopeptide-1 (EGF-like Peptide) |
| CAS Number | 126439-82-5 |
| Synonyms | Oligopeptide-1, EGF-like Peptide, Epidermal Repair Peptide, sh-Oligopeptide-1, INCI: Oligopeptide-1 |
| Molecular Formula | Contact for details |
| Molecular Weight | Contact for details |
| Sequence | 13 amino acids mimicking EGF receptor-binding domain |
| Sequence Length | 13 amino acids |
| Key Modification | N/A |
| Solubility | Soluble in water and aqueous buffers |
| Pharmacological Class | Cosmetic peptide active ingredient / Growth factor mimic |
| Indications | Skin barrier repair, Wound healing, Post-procedure recovery, Sensitive skin care, Anti-aging |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% |
| Grade | Cosmetic Grade / RUO |
Mechanism of Action
Oligopeptide-1 (EGF-like Peptide) is a recombinant polypeptide composed of 13 amino acids designed to mimic the biological activity of human Epidermal Growth Factor (EGF). EGF is a 53-amino-acid protein that plays a critical role in regulating cell growth, proliferation, and differentiation. Oligopeptide-1 captures the receptor-binding domain of EGF, allowing it to interact with the epidermal growth factor receptor (EGFR) on keratinocytes and fibroblasts. Upon binding to EGFR, the peptide activates the receptor's intrinsic tyrosine kinase activity, triggering downstream signaling cascades including the MAPK/ERK and PI3K/Akt pathways. These pathways promote cell cycle progression, DNA synthesis, and cellular proliferation, leading to accelerated epidermal renewal and barrier repair. The peptide also stimulates collagen and elastin production in fibroblasts, improving skin firmness and reducing the appearance of fine lines. Additionally, Oligopeptide-1 enhances the expression of tight junction proteins (occludin, claudin-1) and ceramides, strengthening the skin barrier and reducing transepidermal water loss (TEWL). Its anti-inflammatory properties help soothe sensitive and irritated skin by reducing the release of pro-inflammatory mediators.
Key Features and Benefits
| Feature | Description | Benefit | |
|---|---|---|---|
| ≥99% Purity Verified | ≥99% purity confirmed by HPLC and LC-MS with full batch COA | Ensures consistent efficacy and safety in cosmetic formulations | |
| EGF Mimic Technology | Recombinant peptide engineered to replicate EGF receptor-binding and signaling | Delivers proven growth factor benefits with enhanced stability and safety | |
| Complete QC Documentation | Full Certificate of Analysis with 12+ test parameters per batch | Supports regulatory compliance and quality assurance programs | |
| EU REACH / FDA Compliant | Manufacturing documentation supports global cosmetic regulations | Enables rapid market entry in North America, Europe, and Asia | |
| Scalable Production | Production capacity from gram to multi-kilogram batches | Supports projects from R&D phase through commercial launch | |
| 3-5 Day Lead Time | In-stock items ship within 3-5 business days globally | Minimizes inventory costs and accelerates product development timelines |
Applications and Formulations
Quality Standards and COA Specifications
| Test Item | Specification | Method |
|---|---|---|
| Appearance | White to off-white lyophilized powder | Visual Inspection |
| Peptide Purity (HPLC) | ≥99.0% | RP-HPLC |
| Identity (MS) | Molecular weight matches theoretical | LC-MS/ESI-MS |
| Single Impurity | ≤0.5% | RP-HPLC |
| Total Impurities | ≤1.0% | RP-HPLC |
| Water Content | ≤5.0% | Karl Fischer |
| Acetate Content | Report | HPLC |
| pH (1% solution) | 3.0 - 6.0 | pH Meter |
| Microbial Limits | TAMC ≤100 CFU/g; TYMC ≤50 CFU/g | USP <61> |
| Endotoxin | <10 EU/g | LAL Test |
Full batch-specific COA provided with each shipment. Contact us for historical COA requests.
Packaging and Storage
Packaging Details
Storage and Handling
Regulatory Documentation Support
Certificate of Analysis (COA)
Full batch-specific COA with HPLC, MS, and microbial test results provided with every shipment
Material Safety Data Sheet (MSDS)
Comprehensive safety documentation for handling, storage, and transport
EU REACH Compliance
Registration, Evaluation, Authorization and Restriction of Chemicals documentation available
FDA Facility Registration
Manufacturing facility registered with US FDA for cosmetic ingredient production
ISO 9001 Quality Management
Quality management system certified to ISO 9001:2015 standards
Stability Data
Real-time and accelerated stability data available upon request
Global Export Capabilities
| Region | Capabilities | Documentation |
|---|---|---|
North America (USA, Canada) | Direct shipment with customs documentation; FDA-compliant COA provided | FDA-compliant COA, commercial invoice, packing list, MSDS |
Europe (EU, UK, Switzerland) | REACH-compliant documentation; CE-marked packaging available | REACH compliance statement, EDQM documentation, COA |
Asia-Pacific (Japan, Korea, Australia) | Regional logistics coordination; local language support | NMPA/PMDA-compliant packages, translated COA available |
Latin America (Brazil, Mexico) | MOH registration support; Spanish/Portuguese documentation | Spanish/Portuguese COA translations, MOH registration support |
Middle East (UAE, Saudi Arabia) | GCC registration support; halal certification available | SFDA-compliant documentation, halal certificate |
One-Stop Supply Chain Services
| Service | Description | Value |
|---|---|---|
| API Sourcing | Direct access to audited GMP manufacturing facilities with validated peptide synthesis capabilities | Ensures consistent quality and full traceability from synthesis to delivery |
| Quality Assurance | Independent batch release testing with full analytical documentation and certificate of analysis | Reduces quality risk and accelerates regulatory approval timelines |
| Technical Consultation | Dedicated account manager and technical team for formulation development and stability studies | Expert guidance throughout product development and commercialization |
| Regulatory Support | Complete CMC documentation, stability data, and regulatory filing assistance | Accelerates product registration in target global markets |
| Logistics Management | End-to-end cold chain logistics with temperature monitoring and customs brokerage | Ensures product integrity and on-time delivery worldwide |
Frequently Asked Questions
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