Carnosine — Cosmetic Peptide Raw Material
≥99% Purity

Applications

Carnosine is widely used in cosmetic and skincare formulations for premium product development.

Skin brighteningMelanin inhibitionTone eveningSpot correctionHyperpigmentation treatmentLuminosity enhancement

Carnosine — Cosmetic Peptide Raw Material

High-purity peptide API for cosmetic formulations and skincare research

CarnosineL-CarnosineBeta-Alanyl-L-HistidineINCI: Carnosine
CAS No.305-84-0
Purity≥99%
ShippingGlobal
GradeCosmetic Grade / RUO
MOQ50-100mg
Lead Time3-5 Days

Product Overview

Carnosine (INCI: Carnosine), also known as β-Alanyl-L-Histidine, CAS 305-84-0, sequence: β-Ala-His. CosIng listed. A naturally occurring dipeptide with an excellent safety record.

Potent antioxidant, scavenges free radicals. Anti-glycation agent, inhibits formation of advanced glycation end-products (AGEs), delaying skin aging. Chelates heavy metals for detoxification. Promotes wound healing and skin repair.

Typical applications: Anti-aging serums, anti-glycation products, overnight recovery products. Recommended concentration: 0.1% – 2%.

A classic anti-glycation ingredient experiencing renewed demand with the rising "anti-glycation" trend, affordable and cost-effective.

Product Identification and Specifications

Product NameCarnosine
CAS Number305-84-0
SynonymsCarnosine, L-Carnosine, Beta-Alanyl-L-Histidine, INCI: Carnosine
Molecular FormulaContact for details
Molecular WeightContact for details
SequenceContact for details
Sequence LengthContact for details
Key ModificationN/A
SolubilitySoluble in water and aqueous buffers
Pharmacological ClassCosmetic peptide active ingredient
IndicationsSkin brightening, Melanin inhibition, Tone evening
AppearanceWhite to off-white powder
Purity≥99%
GradeCosmetic Grade / RUO

Mechanism of Action

Carnosine (β-Alanyl-L-Histidine) is a naturally occurring dipeptide found in high concentrations in human muscle and brain tissue. In skin care, carnosine exerts its anti-aging effects through multiple complementary mechanisms. First, as a potent antioxidant, it scavenges reactive oxygen species (ROS) and reactive nitrogen species (RNS), protecting skin cells from oxidative stress. Second, and most importantly, carnosine is a highly effective anti-glycation agent — it inhibits the Maillard reaction (non-enzymatic glycation) where sugar molecules bind to proteins like collagen and elastin, forming advanced glycation end-products (AGEs) that cause skin yellowing, stiffness, and wrinkle formation. Carnosine also exhibits metal-chelating properties, binding to transition metal ions (Cu²⁺, Fe²⁺) that catalyze oxidative reactions. Additionally, the dipeptide promotes wound healing by stimulating fibroblast proliferation and collagen synthesis, and it helps maintain telomere length in skin cells, contributing to its longevity-promoting effects.

Key Features and Benefits

FeatureDescriptionBenefit
≥99% Purity Verified≥99% purity confirmed by HPLC and LC-MS with full batch COAEnsures consistent efficacy and safety in cosmetic formulations
Complete QC DocumentationFull Certificate of Analysis with 12+ test parameters per batchSupports regulatory compliance and quality assurance programs
EU REACH / FDA CompliantManufacturing documentation supports global cosmetic regulationsEnables rapid market entry in North America, Europe, and Asia
Multiple Dosage FormsAvailable as raw powder and lyophilized powderFlexibility for different formulation requirements and stability needs
Scalable ProductionProduction capacity from gram to multi-kilogram batchesSupports projects from R&D phase through commercial launch
3-5 Day Lead TimeIn-stock items ship within 3-5 business days globallyMinimizes inventory costs and accelerates product development timelines

Applications and Formulations

Brightening serums
Spot-correcting creams
Tone-evening essences
Radiance boosters
Anti-pigmentation treatments

Quality Standards and COA Specifications

Test ItemSpecificationMethod
AppearanceWhite to off-white powderVisual Inspection
Peptide Purity (HPLC)≥99.0%RP-HPLC
Identity (MS)Molecular weight matches theoreticalLC-MS/ESI-MS
Single Impurity≤0.5%RP-HPLC
Total Impurities≤1.0%RP-HPLC
Water Content≤5.0%Karl Fischer
Acetate ContentReportHPLC
pH (1% solution)3.0 - 6.0pH Meter
Microbial LimitsTAMC ≤100 CFU/g; TYMC ≤50 CFU/gUSP <61>
Endotoxin<10 EU/gLAL Test

Full batch-specific COA provided with each shipment. Contact us for historical COA requests.

Packaging and Storage

Packaging Details

Standard PackagingSealed aluminum foil bag with desiccant inside rigid container
Available Sizes10mg, 100mg, 1g, 10g, 100g (custom sizes available)
Custom OptionsPrivate labeling, custom vial sizes, and vacuum-sealed packaging available upon request

Storage and Handling

Storage Conditions-20°C ± 5°C, protected from light and moisture, under inert atmosphere
Shelf Life24 months from date of manufacture (when stored as recommended)
ShippingTemperature-controlled packaging with ice packs; cold chain maintained throughout transit

Regulatory Documentation Support

Certificate of Analysis (COA)

Full batch-specific COA with HPLC, MS, and microbial test results provided with every shipment

Material Safety Data Sheet (MSDS)

Comprehensive safety documentation for handling, storage, and transport

EU REACH Compliance

Registration, Evaluation, Authorization and Restriction of Chemicals documentation available

FDA Facility Registration

Manufacturing facility registered with US FDA for cosmetic ingredient production

ISO 9001 Quality Management

Quality management system certified to ISO 9001:2015 standards

Stability Data

Real-time and accelerated stability data available upon request

Global Export Capabilities

RegionCapabilitiesDocumentation
North America (USA, Canada)
Direct shipment with customs documentation; FDA-compliant COA providedFDA-compliant COA, commercial invoice, packing list, MSDS
Europe (EU, UK, Switzerland)
REACH-compliant documentation; CE-marked packaging availableREACH compliance statement, EDQM documentation, COA
Asia-Pacific (Japan, Korea, Australia)
Regional logistics coordination; local language supportNMPA/PMDA-compliant packages, translated COA available
Latin America (Brazil, Mexico)
MOH registration support; Spanish/Portuguese documentationSpanish/Portuguese COA translations, MOH registration support
Middle East (UAE, Saudi Arabia)
GCC registration support; halal certification availableSFDA-compliant documentation, halal certificate

One-Stop Supply Chain Services

ServiceDescriptionValue
API SourcingDirect access to audited GMP manufacturing facilities with validated peptide synthesis capabilitiesEnsures consistent quality and full traceability from synthesis to delivery
Quality AssuranceIndependent batch release testing with full analytical documentation and certificate of analysisReduces quality risk and accelerates regulatory approval timelines
Technical ConsultationDedicated account manager and technical team for formulation development and stability studiesExpert guidance throughout product development and commercialization
Regulatory SupportComplete CMC documentation, stability data, and regulatory filing assistanceAccelerates product registration in target global markets
Logistics ManagementEnd-to-end cold chain logistics with temperature monitoring and customs brokerageEnsures product integrity and on-time delivery worldwide

Frequently Asked Questions

Our Carnosine is ≥99% pure as verified by HPLC analysis. Each batch ships with a comprehensive Certificate of Analysis (COA) documenting purity, identity, and microbial test results. We maintain consistent batch-to-batch quality through validated solid-phase peptide synthesis (SPPS) and rigorous quality control procedures.
All-in-One Service

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Beyond raw peptide supply, Zhaoke Biotech offers end-to-end production solutions — from custom synthesis and process development to scale-up manufacturing, QC testing, and regulatory documentation. Partner with us for a seamless peptide supply chain experience.

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Get a free, no-obligation quotation within 24 hours. Our technical team is standing by to assist with your formulation needs, regulatory questions, and custom requirements.

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Zhaoke Biotech is a leading manufacturer of high-purity peptides for cosmetic, pharmaceutical, nutrition, and research applications. Our product catalog includes over 190 cosmetic peptides, 80+ pharmaceutical peptide APIs, and comprehensive custom synthesis services. All products are manufactured under strict quality control with full analytical documentation including HPLC purity analysis, LC-MS identity confirmation, and comprehensive COA (Certificate of Analysis). We support global shipping with temperature-controlled logistics and provide regulatory documentation including REACH compliance, GMP certificates, and DMF/ASMF filing support. Contact our team today for a competitive quote on Carnosine or any other peptide in our catalog.

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