Antide

Antide is a GnRH (gonadotropin-releasing hormone) antagonist and a synthetic decapeptide used in assisted reproductive technology (IVF/ART) to prevent premature LH surge. As an early-generation GnRH antagonist, Antide competitively blocks pituitary GnRH receptors to rapidly suppress LH and FSH release, effectively controlling ovulation timing and improving success rates in ovarian stimulation cycles. Its chemical structure, optimized with D-amino acid modifications and nicotinyl-lysine residues, significantly enhances GnRH receptor affinity and proteolytic stability.